Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis.

doi:10.1038/s41598-021-95762-5

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Article

Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis.

Scientific reports - 9 Aug 2021

Prieto-Peña Diana, Remuzgo-Martínez Sara, Genre Fernanda, Pulito-Cueto Verónica, Atienza-Mateo Belén, Llorca Javier, Sevilla-Pérez Belén, Ortego-Centeno Norberto, Marquez Ana, Lera-Gómez Leticia, Leonardo María Teresa, Peñalba Ana, Narváez Javier, Martín-Penagos Luis, Rodrigo Emilio, Miranda-Filloy José A, Caminal-Montero Luis, Collado Paz, Sánchez Pérez Javier, de Argila Diego, Rubio Esteban, León Luque Manuel, Blanco-Madrigal Juan María, Galíndez-Agirregoikoa Eva, Gualillo Oreste, Martín Javier, Castañeda Santos, Blanco Ricardo, González-Gay Miguel A, López-Mejías Raquel

Abstract excerpt

Cytokines signalling pathway genes are crucial factors of the genetic network underlying the pathogenesis of Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular condition. An influence of the interleukin (IL)33- IL1 receptor like (IL1RL)1 signalling pathway on the increased risk of several immune-mediated diseases has been described. Accordingly, we assessed whether the IL33-IL1RL1 pathway represents a...

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PMID: 34373564
DOI: 10.1038/s41598-021-95762-5
PMCID: PMC8352942

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