Article
IL-33 Gene Polymorphisms as Potential Biomarkers of Disease Susceptibility and Response to TNF Inhibitors in Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis Patients.
Frontiers in immunology - 1 Jan 2021
Iwaszko Milena, Wielińska Joanna, Świerkot Jerzy, Kolossa Katarzyna, Sokolik Renata, Bugaj Bartosz, Chaszczewska-Markowska Monika, Jeka Sławomir, Bogunia-Kubik Katarzyna
Abstract excerpt
Objective: Rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) belong to inflammatory rheumatic diseases, the group of conditions of unknown etiology. However, a strong genetic component in their pathogenesis has been well established. A dysregulation of cytokine networks plays an important role in the development of inflammatory arthritis. Interleukin 33 (IL-33) is a recently...
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