Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The E3 ubiquitin ligase parkin is dispensable for metabolic homeostasis in murine pancreatic β cells and adipocytes

16 Mar 2019

Abstract excerpt

The E3 ubiquitin ligase parkin is a critical regulator of mitophagy and has been identified as a susceptibility gene for type 2 diabetes (T2D). However, its role in metabolically active tissues that precipitate T2D development is unknown. Specifically, pancreatic β cells and adipocytes both rely heavily on mitochondrial function in the regulation of optimal glycemic control to prevent T2D, but parkin's role in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Autophagy in Disease and Therapy
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30877201
DOI: 10.1074/jbc.ra118.006763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The E3 ubiquitin ligase parkin is dispensable for metabolic homeostasis in murine pancreatic β cells and adipocytesPMID 30877201Read ↗

PINK1-dependent and Parkin-independent mitophagy is involved in reprogramming of glycometabolism in pancreatic cancer cellsSemantic proximity Read ↗

Loss of Prohibitin Induces Mitochondrial Damages Altering β-Cell Function and Survival and Is Responsible for Gradual Diabetes DevelopmentSemantic proximity Read ↗

Hidden phenotypes of PINK1/Parkin knockout mice.Semantic proximity Read ↗

Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytesSemantic proximity Read ↗

Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in miceSemantic proximity Read ↗

Reduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis, inflammation and fibrosisSemantic proximity Read ↗

Mitophagy protects beta cells from inflammatory damage in diabetesSemantic proximity Read ↗

Differential Expression of Ormdl Genes in the Islets of Mice and Humans with ObesitySemantic proximity Read ↗

The PARK2 gene is involved in the maintenance of pancreatic β-cell functions related to insulin production and secretion.Semantic proximity Read ↗

Role of autophagy in <i>β</i> ‐cell function and massSemantic proximity Read ↗

Mitochondrial regulation of β-cell function: maintaining the momentum for insulin release.Semantic proximity Read ↗

Parkin coordinates mitochondrial lipid remodeling to execute mitophagySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.