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Article

Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis.

Molecular and cellular biology - 1 Nov 2009

Matsushita Takehiko, Chan Yuk Yu, Kawanami Aya, Balmes Gener, Landreth Gary E, Murakami Shunichi

Abstract excerpt

Osteoblasts and chondrocytes arise from common osteo-chondroprogenitor cells. We show here that inactivation of ERK1 and ERK2 in osteo-chondroprogenitor cells causes a block in osteoblast differentiation and leads to ectopic chondrogenic differentiation in the bone-forming region in the perichondrium. Furthermore, increased mitogen-activated protein kinase signaling in mesenchymal cells enhances osteoblast...

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Source

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Identifiers

PMID: 19737917
DOI: 10.1128/MCB.01549-08
PMCID: PMC2772724

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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