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Article

Combination versus sequential monotherapy in chronic HBV infection: a mathematical approach.

Mathematical medicine and biology : a journal of the IMA - 1 Dec 2015

Bertacchi Daniela, Zucca Fabio, Foresti Sergio, Mangioni Davide, Gori Andrea

Abstract excerpt

Sequential monotherapy is the most widely used therapeutic approach in the treatment of hepatitis B virus (HBV) chronic infection. Unfortunately, under therapy, in some patients the hepatitis virus mutates and gives rise to variants which are drug resistant. We wonder whether those patients would have benefited from the choice of combination therapy instead of sequential monotherapy. To study the action of these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25398978
DOI: 10.1093/imammb/dqu022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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