Article
A new stochastic model for subgenomic hepatitis C virus replication considers drug resistant mutants.
PloS one - 1 Jan 2014
Ivanisenko Nikita V, Mishchenko Elena L, Akberdin Ilya R, Demenkov Pavel S, Likhoshvai Vitaly A, Kozlov Konstantin N, Todorov Dmitry I, Gursky Vitaly V, Samsonova Maria G, Samsonov Alexander M, Clausznitzer Diana, Kaderali Lars, Kolchanov Nikolay A, Ivanisenko Vladimir A
Abstract excerpt
As an RNA virus, hepatitis C virus (HCV) is able to rapidly acquire drug resistance, and for this reason the design of effective anti-HCV drugs is a real challenge. The HCV subgenomic replicon-containing cells are widely used for experimental studies of the HCV genome replication mechanisms, for drug testing in vitro and in studies of HCV drug resistance. The NS3/4A protease is essential for virus replication...
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