Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combination antiviral therapy for influenza: predictions from modeling of human infections.

The Journal of infectious diseases - 1 Jun 2012

Perelson Alan S, Rong Libin, Hayden Frederick G

Abstract excerpt

Emergence of resistance is a major concern in influenza antiviral treatment and prophylaxis. Combination antiviral therapy might overcome this problem. Here, we estimate that all possible single mutants and a sizeable fraction of double mutants are generated during an uncomplicated influenza infection. While most of them may sustain a fitness cost, some variants may confer drug resistance and be selected during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Chemoprevention
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Therapy, Combination

Share to Influenza, Human

Share to Models, Theoretical

Share to Orthomyxoviridae

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 22448006
DOI: 10.1093/infdis/jis265
PMCID: PMC3415857

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combination antiviral therapy for influenza: predictions from modeling of human infections.PMID 22448006Read ↗

Modelling the emergence of influenza drug resistance: The roles of surface proteins, the immune response and antiviral mechanisms.Semantic proximity Read ↗

Rapid emergence of protease inhibitor resistance in hepatitis C virus.Semantic proximity Read ↗

Antiviral agents for influenza: molecular targets, concerns of resistance, and new treatment options.Semantic proximity Read ↗

Combinations of Host- and Virus-Targeting Antiviral Drugs Confer Synergistic Suppression of SARS-CoV-2Semantic proximity Read ↗

Adherence and drug resistance: predictions for therapy outcomeSemantic proximity Read ↗

Triple combination antiviral drug (TCAD) composed of amantadine, oseltamivir, and ribavirin impedes the selection of drug-resistant influenza A virus.Semantic proximity Read ↗

Mathematical modeling of multi-drugs therapy: a challenge for determining the optimal combinations of antiviral drugs.Semantic proximity Read ↗

Population-Wide Emergence of Antiviral Resistance during Pandemic InfluenzaSemantic proximity Read ↗

Methods for optimizing antiviral combination therapies.Semantic proximity Read ↗

Rational design and adaptive management of combination therapies for Hepatitis C virus infectionSemantic proximity Read ↗

Combination versus sequential monotherapy in chronic HBV infection: a mathematical approach.Semantic proximity Read ↗

Emergence of drug-resistant influenza virus: population dynamical considerations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.