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Article

The role of backward mutations on the within-host dynamics of HIV-1.

Journal of mathematical biology - 1 Nov 2013

Kitayimbwa John M, Mugisha Joseph Y T, Saenz Roberto A

Abstract excerpt

The quality of life for patients infected with human immunodeficiency virus (HIV-1) has been positively impacted by the use of antiretroviral therapy (ART). However, the benefits of ART are usually halted by the emergence of drug resistance. Drug-resistant strains arise from virus mutations, as HIV-1 reverse transcription is prone to errors, with mutations normally carrying fitness costs to the virus. When ART is...

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Identifiers

PMID: 22955525
DOI: 10.1007/s00285-012-0581-2
PMCID: PMC4909148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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