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Friend or foe? The case of Wilms' Tumor 1 (WT1) mutations in acute myeloid leukemia.

Blood cells, molecules & diseases - 1 May 2021

Awada Hassan, Durmaz Arda, Gurnari Carmelo, Kishtagari Ashwin, Zawit Misam, Pagliuca Simona, Visconte Valeria

Abstract excerpt

Wilms tumor 1 (WT1) gene is commonly mutated in acute myeloid leukemia (AML), particularly in younger age population. The mechanism through which WT1 mutations drive leukemogenesis have not been fully elucidated; however, recent studies reported an association with the epigenetic pathway. Here, we studied the phenotypic characteristics and somatic mutational profile of 114 WT1-mutant AML patients and focused on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33636567
DOI: 10.1016/j.bcmd.2021.102549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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