Reproducible simulations of realistic samples for next-generation sequencing studies using Variant Simulation Tools.

Abstract excerpt

Computer simulations have been widely used to validate and evaluate the power of statistical methods for genetic epidemiological studies. Although a large number of simulation methods and software packages have been developed for genome-wide association studies, methodological and bioinformatics challenges have limited their applications in simulating datasets for whole-genome and whole-exome sequencing studies....

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