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Article

Genome simulation approaches for synthesizing in silico datasets for human genomics.

Advances in genetics - 1 Jan 2010

Ritchie Marylyn D, Bush William S

Abstract excerpt

Simulated data is a necessary first step in the evaluation of new analytic methods because in simulated data the true effects are known. To successfully develop novel statistical and computational methods for genetic analysis, it is vital to simulate datasets consisting of single nucleotide polymorphisms (SNPs) spread throughout the genome at a density similar to that observed by new high-throughput molecular...

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PMID: 21029846
DOI: 10.1016/B978-0-12-380862-2.00001-1

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