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Article

Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jan 2015

Raff Hershel, Gehrand Ashley, Bruder Eric D, Hoffman Matthew J, Engeland William C, Moreno Carol

Abstract excerpt

The classic renin-angiotensin system is partly responsible for controlling aldosterone secretion from the adrenal cortex via the peptide angiotensin II (ANG II). In addition, there is a local adrenocortical renin-angiotensin system that may be involved in the control of aldosterone synthesis in the zona glomerulosa (ZG). To characterize the long-term control of adrenal steroidogenesis, we utilized adrenal glands...

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Identifiers

PMID: 25394830
DOI: 10.1152/ajpregu.00440.2014
PMCID: PMC4281677

Genes

ANG
ZFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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