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Article

Investigating the effects of cysteine-118 oxidation on G12D KRas structure and dynamics: insights from MD simulations.

Journal of biomolecular structure & dynamics - 1 Aug 2024

Salamh Shimaa, Sayyed-Ahmad Abdallah

Abstract excerpt

Mutations of Ras proteins are believed to be among the most prominent causes of cancer. There is increasing evidence that the activity of Ras may be controlled by the redox state of cysteine residues located within the NKCD motif. This redox signaling is critical to both physiological and pathological processes and occurs when C118 is oxidized in a reversible manner. In this study, we used atomistic molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37480262
DOI: 10.1080/07391102.2023.2238080

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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