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Article

Discoveries in the redox regulation of KRAS.

The international journal of biochemistry & cell biology - 1 Feb 2021

Kramer-Drauberg Maximilian, Ambrogio Chiara

Abstract excerpt

Oncogenic KRAS is one of the most common drivers of human cancer. Despite intense research, no effective therapy to directly inhibit oncogenic KRAS has yet been approved and KRAS mutant tumors remain associated with a poor prognosis. This short review discusses the current knowledge of the redox regulation of RAS and examines the newest findings on cysteine 118 (C118) as a potential novel target for KRAS inhibition.

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Source

Identifiers

PMID: 33309959
DOI: 10.1016/j.biocel.2020.105901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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