Article
Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage.
Journal of thrombosis and haemostasis : JTH - 1 Jan 2015
Pertuy F, Aguilar A, Strassel C, Eckly A, Freund J-N, Duluc I, Gachet C, Lanza F, Léon C
Abstract excerpt
BACKGROUND: Transgenic mice expressing cre recombinase under the control of the platelet factor 4 (Pf4) promoter, in the context of a 100-kb bacterial artificial chromosome, have become a valuable tool with which to study genetic modifications in the platelet lineage. However, the specificity of cre expression has recently been questioned, and the time of its onset during megakaryopoiesis remains unknown....
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