Article
Drep-2 is a novel synaptic protein important for learning and memory.
eLife - 13 Nov 2014
Andlauer Till F M, Scholz-Kornehl Sabrina, Tian Rui, Kirchner Marieluise, Babikir Husam A, Depner Harald, Loll Bernhard, Quentin Christine, Gupta Varun K, Holt Matthew G, Dipt Shubham, Cressy Michael, Wahl Markus C, Fiala André, Selbach Matthias, Schwärzel Martin, Sigrist Stephan J
Abstract excerpt
CIDE-N domains mediate interactions between the DNase Dff40/CAD and its inhibitor Dff45/ICAD. In this study, we report that the CIDE-N protein Drep-2 is a novel synaptic protein important for learning and behavioral adaptation. Drep-2 was found at synapses throughout the Drosophila brain and was strongly enriched at mushroom body input synapses. It was required within Kenyon cells for normal olfactory short- and...
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