Article
Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior.
Nature neuroscience - 1 Jan 2013
Ryan Tomás J, Kopanitsa Maksym V, Indersmitten Tim, Nithianantharajah Jess, Afinowi Nurudeen O, Pettit Charles, Stanford Lianne E, Sprengel Rolf, Saksida Lisa M, Bussey Timothy J, O'Dell Thomas J, Grant Seth G N, Komiyama Noboru H
Abstract excerpt
Two genome duplications early in the vertebrate lineage expanded gene families, including GluN2 subunits of the NMDA receptor. Diversification between the four mammalian GluN2 proteins occurred primarily at their intracellular C-terminal domains (CTDs). To identify shared ancestral functions and diversified subunit-specific functions, we exchanged the exons encoding the GluN2A (also known as Grin2a) and GluN2B...
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