Article
MicroRNA-276a functions in ellipsoid body and mushroom body neurons for naive and conditioned olfactory avoidance in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Mar 2013
Li Wanhe, Cressy Michael, Qin Hongtao, Fulga Tudor, Van Vactor David, Dubnau Josh
Abstract excerpt
MicroRNA (miRNA)-mediated gene regulation plays a key role in brain development and function. But there are few cases in which the roles of individual miRNAs have been elucidated in behaving animals. We report a miR-276a::DopR regulatory module in Drosophila that functions in distinct circuits for naive odor responses and conditioned odor memory. Drosophila olfactory aversive memory involves convergence of the...
Topics
- Analysis of Variance
- Animals
- Animals, Genetically Modified
- Avoidance Learning
- Drosophila
- Drosophila Proteins
- Electroshock
- Embryo, Nonmammalian
- Female
- Gene Expression Regulation, Developmental
- Green Fluorescent Proteins
- Hot Temperature