Article
A transcriptional program promotes remodeling of GABAergic synapses in Caenorhabditis elegans.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Oct 2011
Petersen Sarah C, Watson Joseph D, Richmond Janet E, Sarov Mihail, Walthall Walter W, Miller David M
Abstract excerpt
Although transcription factors are known to regulate synaptic plasticity, downstream genes that contribute to neural circuit remodeling are largely undefined. In Caenorhabditis elegans, GABAergic Dorsal D (DD) motor neuron synapses are relocated to new sites during larval development. This remodeling program is blocked in Ventral D (VD) GABAergic motor neurons by the COUP-TF (chicken ovalbumin upstream promoter...
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