Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic Modification of Histone 3 Lysine 27

13 Nov 2014

Abstract excerpt

The Mediator complex is vital for the transcriptional regulation of eukaryotic genes. Mediator binds to nuclear receptors at target response elements and recruits chromatin-modifying enzymes and RNA polymerase II. Here, we examine the involvement of Mediator subunit MED25 in the epigenetic regulation of human cytochrome P450 2C9 ( CYP2C9 ). MED25 is recruited to the CYP2C9 promoter through association with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Epigenetics and DNA Methylation
Share to Pharmacogenetics and Drug Metabolism

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25391650
DOI: 10.1074/jbc.m114.579474

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic Modification of Histone 3 Lysine 27PMID 25391650Read ↗

Vitamin D and the epigenomeSemantic proximity Read ↗

Genome-wide discovery of drug-dependent human liver regulatory elements.Semantic proximity Read ↗

Morphine leads to global genome changes in H3K27me3 levels via a Polycomb Repressive Complex 2 (PRC2) self-regulatory mechanism in mESCsSemantic proximity Read ↗

Drug-induced cis-regulatory elements in human hepatocytes affect molecular phenotypes associated with adverse reactionsSemantic proximity Read ↗

JMJD3 is a histone H3K27 demethylase.Semantic proximity Read ↗

Cis-acting regulatory elements regulating CYP3A4 transcription in human liver.Semantic proximity Read ↗

MED19 Regulates Adipogenesis and Maintenance of White Adipose Tissue Mass by Mediating PPARγ-Dependent Gene ExpressionSemantic proximity Read ↗

The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.Semantic proximity Read ↗

A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase‐2 in idiopathic pulmonary fibrosisSemantic proximity Read ↗

Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription.Semantic proximity Read ↗

HCV infection activates the proteasome via PA28γ acetylation and heptamerization to facilitate the degradation of RNF2, a catalytic component of polycomb repressive complex 1Semantic proximity Read ↗

Quinone reductase 2 <i>reads</i> H3 serotonylation to support neuronal maturationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.