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Article

MED19 Regulates Adipogenesis and Maintenance of White Adipose Tissue Mass by Mediating PPARγ-Dependent Gene Expression

1 Oct 2020

Abstract excerpt

The Mediator complex relays regulatory signals from gene-specific transcription factors to the basal transcriptional machinery. However, the role of individual Mediator subunits in different tissues remains unclear. Here, we demonstrate that MED19 is essential for adipogenesis and maintenance of white adipose tissue (WAT) by mediating peroxisome proliferator-activated receptor gamma (PPARγ) transcriptional...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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Identifiers

PMID: 33027649
DOI: 10.1016/j.celrep.2020.108228

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