Article
Somatic mutations favorable to patient survival are predominant in ovarian carcinomas.
PloS one - 1 Jan 2014
Zhang Wensheng, Edwards Andrea, Flemington Erik, Zhang Kun
Abstract excerpt
Somatic mutation accumulation is a major cause of abnormal cell growth. However, some mutations in cancer cells may be deleterious to the survival and proliferation of the cancer cells, thus offering a protective effect to the patients. We investigated this hypothesis via a unique analysis of the clinical and somatic mutation datasets of ovarian carcinomas published by the Cancer Genome Atlas. We defined and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.