Article

Blockade of Cysteine Cathepsin Caused Lysosome Dysfunction and Aggravated Adenine-induced Nephropathy by Inducing Tubular Cell Senescence

2026-06-05

Abstract excerpt

<title>Abstract</title> <p>Lysosomal cysteine cathepsins are a group of endopeptidases which exert critical, context-dependent roles in chronic kidney disease (CKD) with underlying mechanisms incompletely clarified. In this study, we investigated the consequences of pan-cysteine cathepsin inhibition using the pharmacological inhibitor E-64 in C57BL/6 mice with adenine-induced nephropathy (AN), followed by proteom...

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Literature Corpus work: eda1f206-153c-5979-8799-d8838ae99bc1
DOI: 10.21203/rs.3.rs-9890117/v1

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