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Article

Renalase alleviates salt-induced kidney necroptosis and inflammation.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Oct 2024

Wang Yang, Jia Hao, Gao Ke, Du Ming-Fei, Chu Chao, Wang Dan, Ma Qiong, Hu Gui-Lin, Zhang Xi, Sun Yue, Man Zi-Yue, Mu Jian-Jun

Abstract excerpt

Recent evidence suggests that necroptosis may contribute to the development of kidney injury. Renalase is a novel secretory protein that exerts potent prosurvival and anti-inflammatory effects. We hypothesized that renalase could protect the kidney from salt-induced injury by modulating necroptosis. High salt and renalase treatments were administered to Dahl salt-sensitive (SS) rats, renalase knockout (KO) mice,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Monoamine Oxidase

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Share to Receptor-Interacting Protein Serine-Threonine Kinases

Share to Sodium Chloride, Dietary

Source

Identifiers

PMID: 39117946
DOI: 10.1038/s41440-024-01814-4

Genes

MLKL
RIPK1
RIPK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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