Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukaemia.

doi:10.1007/s00251-014-0812-3

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Article

Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukaemia.

Immunogenetics - 1 Jan 2015

Xochelli Aliki, Agathangelidis Andreas, Kavakiotis Ioannis, Minga Evangelia, Sutton Lesley Ann, Baliakas Panagiotis, Chouvarda Ioanna, Giudicelli Véronique, Vlahavas Ioannis, Maglaveras Nikos, Bonello Lisa, Trentin Livio, Tedeschi Alessandra, Panagiotidis Panagiotis, Geisler Christian, Langerak Anton W, Pospisilova Sarka, Jelinek Diane F, Oscier David, Chiorazzi Nicholas, Darzentas Nikos, Davi Fred, Ghia Paolo, Rosenquist Richard, Hadzidimitriou Anastasia, Belessi Chrysoula, Lefranc Marie-Paule, Stamatopoulos Kostas

Abstract excerpt

Νext generation sequencing studies in Homo sapiens have identified novel immunoglobulin heavy variable (IGHV) genes and alleles necessitating changes in the international ImMunoGeneTics information system (IMGT) GENE-DB and reference directories of IMGT/V-QUEST. In chronic lymphocytic leukaemia (CLL), the somatic hypermutation (SHM) status of the clonotypic rearranged IGHV gene is strongly associated with patient...

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PMID: 25388851
DOI: 10.1007/s00251-014-0812-3

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