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Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: updated ERIC recommendations

25 Apr 2017

Abstract excerpt

Pivotal studies from the 1990s offered the first pieces of evidence for the role of immunoglobulin (IG) receptors and antigen stimulation in the natural history of chronic lymphocytic leukemia (CLL). These studies revealed the pronounced skewing of the IG gene repertoire in CLL, strongly implying a role for antigen selection in disease development. 1 , 2 , 3 , 4 In addition, they showed that the presence and load...

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PMID: 28439111
DOI: 10.1038/leu.2017.125

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