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Article

The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL.

Blood - 7 Jan 2010

Forconi Francesco, Potter Kathleen N, Wheatley Isla, Darzentas Nikos, Sozzi Elisa, Stamatopoulos Kostas, Mockridge C Ian, Packham Graham, Stevenson Freda K

Abstract excerpt

The cell of origin of chronic lymphocytic leukemia (CLL) has long been sought, and immunoglobulin gene analysis provides new clues. In the unmutated subset (U-CLL), there is increased usage of the 51p1-related alleles of the immunoglobulin heavy chain variable 1-69 gene, often combined with selected genes and with immunoglobulin heavy chain diversity IGHJ6. Stereotypic characteristics of the HCDR3 result and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Complementarity Determining Regions

Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

Source

Identifiers

PMID: 19887677
DOI: 10.1182/blood-2009-06-225813

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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