Article
Genetically predicted high serum sex hormone-binding globulin levels are associated with lower ischemic stroke risk: A sex-stratified Mendelian randomization study.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Jun 2024
Sun Wei, Wang Yuan, Li Cancan, Yao Xuefan, Wu Xiao, He Aini, Zhao Benke, Huang Xiaoqin, Song Haiqing
Abstract excerpt
OBJECTIVE: Cross-sectional and cohort studies have found insufficient evidence of a causal relationship between sex hormone-binding globulin and ischemic stroke, only associations. Here, we performed a sex-stratified, bidirectional, two-sample Mendelian randomization analysis to evaluate whether a causal relationship exists between sex hormone-binding globulin and ischemic stroke. METHODS: Single-nucleotide...
Topics
- Humans
- Sex Hormone-Binding Globulin
- Mendelian Randomization Analysis
- Male
- Female
- Ischemic Stroke
- Polymorphism, Single Nucleotide
- Risk Factors
- Sex Factors
- Risk Assessment