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Article

PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5.

Blood - 16 Sept 2010

Nigro Patrizia, Abe Jun-ichi, Woo Chang-Hoon, Satoh Kimio, McClain Carolyn, O'Dell Michael R, Lee Hakjoo, Lim Jae-Hyang, Li Jian-dong, Heo Kyung-Sun, Fujiwara Keigi, Berk Bradford C

Abstract excerpt

PKCζ has emerged as a pathologic mediator of endothelial cell dysfunction, based on its essential role in tumor necrosis factor α (TNFα)-mediated inflammation. In contrast, extracellular signal-regulated kinase 5 (ERK5) function is required for endothelial cell homeostasis as shown by activation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20538799
DOI: 10.1182/blood-2010-02-269134
PMCID: PMC3173991

Genes

KLF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20538799-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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