Article
Lack of evidence of the interaction of the Aβ peptide with the Wnt signaling cascade in Drosophila models of Alzheimer's disease.
Molecular brain - 12 Nov 2014
Lüchtenborg Anne-Marie, Katanaev Vladimir L
Abstract excerpt
BACKGROUND: Alzheimer's disease (AD) is the leading form of dementia worldwide. The Aβ-peptide is believed to be the major pathogenic compound of the disease. Since several years it is hypothesized that Aβ impacts the Wnt signaling cascade and therefore activation of this signaling pathway is proposed to rescue the neurotoxic effect of Aβ. FINDINGS: Expression of the human Aβ42 in the Drosophila nervous system...
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