Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synaptic abnormalities in a Drosophila model of Alzheimer's disease.

Disease models & mechanisms - 1 Mar 2014

Mhatre Siddhita D, Satyasi Vivek, Killen Mark, Paddock Brie E, Moir Robert D, Saunders Aleister J, Marenda Daniel R

Abstract excerpt

Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by memory loss and decreased synaptic function. Advances in transgenic animal models of AD have facilitated our understanding of this disorder, and have aided in the development, speed and efficiency of testing potential therapeutics. Recently, we have described the characterization of a novel model of AD in the fruit fly,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Amyloid Precursor Protein Secretases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aspartic Acid Endopeptidases

Share to Behavior, Animal

Share to Motor Neurons

Share to Synapses

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 24487408
DOI: 10.1242/dmm.012104
PMCID: PMC3944497

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synaptic abnormalities in a Drosophila model of Alzheimer's disease.PMID 24487408Read ↗

Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects.Semantic proximity Read ↗

[Morphological and functional abnormalities in neuromuscular junctions of Drosophila melanogaster induced by the expression of human APP gene].Semantic proximity Read ↗

Insights from Drosophila melanogaster model of Alzheimer s diseaseSemantic proximity Read ↗

Drosophila melanogaster: Deciphering Alzheimer's DiseaseSemantic proximity Read ↗

Development and characterization of an aged onset model of Alzheimer's disease in Drosophila melanogaster.Semantic proximity Read ↗

Genetic Dissection of Alzheimer’s Disease Using Drosophila ModelsSemantic proximity Read ↗

Using Drosophila amyloid toxicity models to study Alzheimer's diseaseSemantic proximity Read ↗

Drosophila melanogaster as a model organism for Alzheimer’s diseaseSemantic proximity Read ↗

The Drosophila β-Amyloid Precursor Protein Homolog Promotes Synapse Differentiation at the Neuromuscular JunctionSemantic proximity Read ↗

Investigating how changes in the levels of kinesins impact neuronal health in Drosophila and human iPSC-derived neurons AD model.Semantic proximity Read ↗

Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila.Semantic proximity Read ↗

Invertebrate models of Alzheimer's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.