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Article

Short Aβ peptides attenuate Aβ42 toxicity in vivo.

The Journal of experimental medicine - 2 Jan 2018

Moore Brenda D, Martin Jason, de Mena Lorena, Sanchez Jonatan, Cruz Pedro E, Ceballos-Diaz Carolina, Ladd Thomas B, Ran Yong, Levites Yona, Kukar Thomas L, Kurian Justin J, McKenna Robert, Koo Edward H, Borchelt David R, Janus Christopher, Rincon-Limas Diego, Fernandez-Funez Pedro, Golde Todd E

Abstract excerpt

Processing of amyloid-β (Aβ) precursor protein (APP) by γ-secretase produces multiple species of Aβ: Aβ40, short Aβ peptides (Aβ37-39), and longer Aβ peptides (Aβ42-43). γ-Secretase modulators, a class of Alzheimer's disease therapeutics, reduce production of the pathogenic Aβ42 but increase the relative abundance of short Aβ peptides. To evaluate the pathological relevance of these peptides, we expressed Aβ36-40...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29208777
DOI: 10.1084/jem.20170600
PMCID: PMC5748850

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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