Article
Association of polymorphisms in IL6 gene promoter region with type 1 diabetes and increased albumin-to-creatinine ratio.
Diabetes/metabolism research and reviews - 1 Jul 2015
Ururahy Marcela Abbott Galvão, de Souza Karla Simone Costa, Oliveira Yonara Monique da Costa, Loureiro Melina Bezerra, da Silva Heglayne Pereira Vital, Freire-Neto Francisco Paulo, Bezerra João Felipe, Luchessi André Ducati, Doi Sonia Quateli, Hirata Rosario Dominguez Crespo, Almeida Maria das Graças, Arrais Ricardo Fernando, Hirata Mario Hiroyuki, de Rezende Adriana Augusto
Abstract excerpt
BACKGROUND: Pro-inflammatory cytokines, such as interleukin-6 (IL-6), have been considered as key factors in type 1 diabetes mellitus (T1DM) and diabetic nephropathy, thus, our aim was to investigate the association of IL6-174G>C (rs1800795) and -634C>G (rs1800796) polymorphisms with T1DM susceptibility and diabetic nephropathy. METHODS: These polymorphisms were analyzed in 144 children and adolescents with T1DM...
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