Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.

doi:10.1080/07853890802337037

Article

Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.

Annals of medicine - 1 Jan 2009

Huth Cornelia, Illig Thomas, Herder Christian, Gieger Christian, Grallert Harald, Vollmert Caren, Rathmann Wolfgang, Hamid Yasmin H, Pedersen Oluf, Hansen Torben, Thorand Barbara, Meisinger Christa, Doring Angela, Klopp Norman, Gohlke Henning, Lieb Wolfgang, Hengstenberg Christian, Lyssenko Valeriya, Groop Leif, Ireland Helen, Stephens Jeffrey W, Wernstedt Asterholm Ingrid, Jansson John-Olov, Boeing Heiner, Mohlig Matthias, Stringham Heather M, Boehnke Michael, Tuomilehto Jaakko, Fernandez-Real Jose-Manuel, Lopez-Bermejo Abel, Gallart Luis, Vendrell Joan, Humphries Steve E, Kronenberg Florian, Wichmann H-Erich, Heid Iris M

Abstract excerpt

BACKGROUND: Several studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. AIMS: This joint analysis aimed to clarify whether IL6 -174G>C was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). METHODS:...

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Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.

Abstract excerpt

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