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Article

Meta-analysis: Interleukin 6 gene -174G/C polymorphism associated with type 2 diabetes mellitus and interleukin 6 changes.

Journal of cellular and molecular medicine - 1 Jun 2021

Cheng Hao, Zhu Wenbin, Zhu Mou, Sun Yan, Sun Xiaojie, Jia Di, Yang Chao, Yu Haitao, Zhang Chunjing

Abstract excerpt

The gene coding interleukin 6 (IL-6) is a promising candidate in predisposition to type 2 diabetes mellitus (T2DM). This study aimed to meta-analytically examine the association of IL-6 gene -174G/C polymorphism with T2DM and circulating IL-6 changes across -174G/C genotypes. Odds ratio (OR) and standard mean difference (SMD) with 95% confidence interval (CI) were calculated. Twenty-five articles were...

Topics

Diabetes Mellitus, Type 2
Genetic Predisposition to Disease
Genotype
Humans
Interleukin-6
Polymorphism, Single Nucleotide
Risk Factors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33960655
DOI: 10.1111/jcmm.16575
PMCID: PMC8184671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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