Article
Characteristics of CARMA1-BCL10-MALT1-A20-NF-κB expression in T cell-acute lymphocytic leukemia.
European journal of medical research - 11 Nov 2014
Ma Yu, Liao Ziwei, Xu Yi, Zhong Ziyun, Wang Xu, Zhang Fan, Chen Shaohua, Yang Lijian, Luo Gengxin, Huang Xin, Huang Suming, Wu Xiuli, Li Yangqiu
Abstract excerpt
BACKGROUND: Knowledge of the oncogenic signaling pathways of T-cell acute lymphoblastic leukemia (T-ALL) remains limited. Constitutive aberrant activation of the nuclear factor kappa B (NF-κB) signaling pathway has been detected in various lymphoid malignancies and plays a key role in the development of these carcinomas. The zinc finger-containing protein, A20, is a central regulator of multiple NF-κB-activating...
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