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Transcriptome and Regulatory Network Analyses of CD19-CAR-T Immunotherapy for B-ALL

1 Apr 2019

Abstract excerpt

Abstract Chimeric antigen receptor (CAR) T cell therapy has exhibited dramatic anti-tumor efficacy in clinical trials. In this study, we reported the transcriptome profiles of bone marrow cells in four B cell acute lymphoblastic leukemia (B-ALL) patients before and after CD19-specific CAR-T therapy. CD19-CAR-T therapy remarkably reduced the number of leukemia cells, and three patients achieved bone marrow...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 31201998
DOI: 10.1016/j.gpb.2018.12.008

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