Article
Characteristics of A20 gene polymorphisms in T-cell acute lymphocytic leukemia.
Hematology (Amsterdam, Netherlands) - 1 Dec 2014
Zhu Lihua, Zhang Fan, Shen Qi, Chen Shaohua, Wang Xu, Wang Liang, Yang Lijian, Wu Xiuli, Huang Suming, Schmidt Christian A, Li Yangqiu
Abstract excerpt
A20 is a repressor of NF-κB and was recently shown to be frequently inactivated by deletions or mutations in several types of lymphomas including T-cell lymphoma. Little is known about the characteristics of A20 mutations in T-cell acute lymphoblastic leukemia (T-ALL). In this study, we analyzed A20 polymorphisms and characterized their features in 11 cases with T-ALL, 30 samples from healthy Chinese individuals,...
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