Article
Identifying genetic variants for heart rate variability in the acetylcholine pathway.
PloS one - 1 Jan 2014
Riese Harriëtte, Muñoz Loretto M, Hartman Catharina A, Ding Xiuhua, Su Shaoyong, Oldehinkel Albertine J, van Roon Arie M, van der Most Peter J, Lefrandt Joop, Gansevoort Ron T, van der Harst Pim, Verweij Niek, Licht Carmilla M M, Boomsma Dorret I, Hottenga Jouke-Jan, Willemsen Gonneke, Penninx Brenda W J H, Nolte Ilja M, de Geus Eco J C, Wang Xiaoling, Snieder Harold
Abstract excerpt
Heart rate variability is an important risk factor for cardiovascular disease and all-cause mortality. The acetylcholine pathway plays a key role in explaining heart rate variability in humans. We assessed whether 443 genotyped and imputed common genetic variants in eight key genes (CHAT, SLC18A3, SLC5A7, CHRNB4, CHRNA3, CHRNA, CHRM2 and ACHE) of the acetylcholine pathway were associated with variation in an...
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