Article
Genome-wide association analysis identifies multiple loci related to resting heart rate.
Human molecular genetics - 1 Oct 2010
Eijgelsheim Mark, Newton-Cheh Christopher, Sotoodehnia Nona, de Bakker Paul I W, Müller Martina, Morrison Alanna C, Smith Albert V, Isaacs Aaron, Sanna Serena, Dörr Marcus, Navarro Pau, Fuchsberger Christian, Nolte Ilja M, de Geus Eco J C, Estrada Karol, Hwang Shih-Jen, Bis Joshua C, Rückert Ina-Maria, Alonso Alvaro, Launer Lenore J, Hottenga Jouke Jan, Rivadeneira Fernando, Noseworthy Peter A, Rice Kenneth M, Perz Siegfried, Arking Dan E, Spector Tim D, Kors Jan A, Aulchenko Yurii S, Tarasov Kirill V, Homuth Georg, Wild Sarah H, Marroni Fabio, Gieger Christian, Licht Carmilla M, Prineas Ronald J, Hofman Albert, Rotter Jerome I, Hicks Andrew A, Ernst Florian, Najjar Samer S, Wright Alan F, Peters Annette, Fox Ervin R, Oostra Ben A, Kroemer Heyo K, Couper David, Völzke Henry, Campbell Harry, Meitinger Thomas, Uda Manuela, Witteman Jacqueline C M, Psaty Bruce M, Wichmann H-Erich, Harris Tamara B, Kääb Stefan, Siscovick David S, Jamshidi Yalda, Uitterlinden André G, Folsom Aaron R, Larson Martin G, Wilson James F, Penninx Brenda W, Snieder Harold, Pramstaller Peter P, van Duijn Cornelia M, Lakatta Edward G, Felix Stephan B, Gudnason Vilmundur, Pfeufer Arne, Heckbert Susan R, Stricker Bruno H Ch, Boerwinkle Eric, O'Donnell Christopher J
Abstract excerpt
Higher resting heart rate is associated with increased cardiovascular disease and mortality risk. Though heritable factors play a substantial role in population variation, little is known about specific genetic determinants. This knowledge can impact clinical care by identifying novel factors that influence pathologic heart rate states, modulate heart rate through cardiac structure and function or by improving...
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