Article
Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study.
BMC medical genetics - 14 Jul 2008
McArdle Patrick F, Rutherford Sue, Mitchell Braxton D, Damcott Coleen M, Wang Ying, Ramachandran Vasan, Ott Sandy, Chang Yen-Pei C, Levy Daniel, Steinle Nanette
Abstract excerpt
BACKGROUND: Systemic blood pressure, influenced by both genetic and environmental factors, is regulated via sympathetic nerve activity. We assessed the role of genetic variation in three subunits of the neuromuscular nicotinic acetylcholine receptor positioned on chromosome 2q, a region showing replicated evidence of linkage to blood pressure. METHODS: We sequenced CHRNA1, CHRND and CHRNG in 24 Amish subjects...
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