Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.

Nature communications - 16 May 2018

Ramírez Julia, Duijvenboden Stefan van, Ntalla Ioanna, Mifsud Borbala, Warren Helen R, Tzanis Evan, Orini Michele, Tinker Andrew, Lambiase Pier D, Munroe Patricia B

Abstract excerpt

Impaired capacity to increase heart rate (HR) during exercise (ΔHRex), and a reduced rate of recovery post-exercise (ΔHRrec) are associated with higher cardiovascular mortality rates. Currently, the genetic basis of both phenotypes remains to be elucidated. We conduct genome-wide association studies (GWASs) for ΔHRex and ΔHRrec in ~40,000 individuals, followed by replication in ~27,000 independent samples, all...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autonomic Nervous System
Share to Cardiovascular Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exercise

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Heart Rate

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 29769521
DOI: 10.1038/s41467-018-04148-1
PMCID: PMC5955978

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.PMID 29769521Read ↗

Genetic study links components of the autonomous nervous system to heart-rate profile during exerciseSemantic proximity Read ↗

Genetic study links components of the autonomous nervous system to heart-rate profile during exerciseSemantic proximity Read ↗

No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization AnalysisSemantic proximity Read ↗

Genome-wide association analysis identifies multiple loci related to resting heart rate.Semantic proximity Read ↗

Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.Semantic proximity Read ↗

Genomics of Cardiovascular Measures of Autonomic Tone.Semantic proximity Read ↗

Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease.Semantic proximity Read ↗

Genome-wide association studies and resting heart rate.Semantic proximity Read ↗

Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise.Semantic proximity Read ↗

Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs.Semantic proximity Read ↗

Genetic insights into resting heart rate and its role in cardiovascular disease.Semantic proximity Read ↗

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.