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Developing enhanced immunotherapy using NKG2A knockout human pluripotent stem cell-derived NK cells

23 Oct 2024

Abstract excerpt

Cancer immunotherapy is gaining increasing attention. However, immune checkpoints are exploited by cancer cells to evade anti-tumor immunotherapy. Here, we knocked out NKG2A, an immune checkpoint expressed on natural killer (NK) cells, in human pluripotent stem cells (hPSCs) and differentiated these hPSCs into NK (PSC-NK) cells. We show that NKG2A knockout (KO) enhances the anti-tumor and anti-viral capabilities...

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PMID: 39447568
DOI: 10.1016/j.celrep.2024.114867

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