Article
Identification of a Natural Killer Cell Receptor Allele That Prolongs Survival of Cytomegalovirus-Positive Glioblastoma Patients.
Cancer research - 15 Sept 2016
Dominguez-Valentin Mev, Gras Navarro Andrea, Rahman Aminur Mohummad, Kumar Surendra, Retière Christèle, Ulvestad Elling, Kristensen Vessela, Lund-Johansen Morten, Lie Benedicte Alexandra, Enger Per Øyvind, Njølstad Gro, Kristoffersen Einar, Lie Stein Atle, Chekenya Martha
Abstract excerpt
By affecting immunological presentation, the presence of cytomegalovirus in some glioblastomas may impact progression. In this study, we examined a hypothesized role for natural killer (NK) cells in impacting disease progression in this setting. We characterized 108 glioblastoma patients and 454 healthy controls for HLA-A,-B,-C, NK-cell KIR receptors, and CMV-specific antibodies and correlated these metrics with...
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