TCR signaling events are required for maintaining CD4 regulatory T cell numbers and suppressive capacities in the periphery.

doi:10.4049/jimmunol.1400477

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TCR signaling events are required for maintaining CD4 regulatory T cell numbers and suppressive capacities in the periphery.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2014

Delpoux Arnaud, Yakonowsky Philippe, Durand Aurélie, Charvet Céline, Valente Michael, Pommier Arnaud, Bonilla Nelly, Martin Bruno, Auffray Cédric, Lucas Bruno

Abstract excerpt

CD4 regulatory T cells (Tregs) can be subdivided into two subsets according to Ly-6C expression in the periphery. Phenotypic analysis, imaging, and adoptive-transfer experiments of peripheral Ly-6C(-) and Ly-6C(+) Tregs reveal that the nonexpression of Ly-6C by ∼70% of peripheral Tregs depends on TCR signaling events. Interestingly, Ly-6C(-) Tregs express higher surface amounts of key immunosuppressive molecules...

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TCR signaling events are required for maintaining CD4 regulatory T cell numbers and suppressive capacities in the periphery.

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