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Article

Phenotypic and Functional Changes of Peripheral Ly6C+ T Regulatory Cells Driven by Conventional Effector T Cells.

Frontiers in immunology - 1 Jan 2018

Lee Jun Young, Kim Juhee, Yi Jaeu, Kim Daeun, Kim Hee-Ok, Han Daehee, Sprent Jonathan, Lee You Jeong, Surh Charles D, Cho Jae-Ho

Abstract excerpt

A relatively high affinity/avidity of T cell receptor (TCR) recognition for self-peptide bound to major histocompatibility complex II (self-pMHC) ligands is a distinctive feature of CD4 T regulatory (Treg) cells, including their development in the thymus and maintenance of their suppressive functions in the periphery. Despite such high self-reactivity, however, all thymic-derived peripheral Treg populations are...

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Identifiers

PMID: 29616017
DOI: 10.3389/fimmu.2018.00437
PMCID: PMC5864862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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