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Article

SLCO1B1 gene variability influences lipid-lowering efficacy on simvastatin therapy in Southern Brazilians.

Clinical chemistry and laboratory medicine - 1 Mar 2012

Sortica Vinicius A, Fiegenbaum Marilu, Lima Luciana O, Van der Sand Cézar R, Van der Sand Luis C, Ferreira Maria E W, Pires Renan C, Hutz Mara H

Abstract excerpt

BACKGROUND: Variants in uptake and efflux transporters can influence diverse statin pharmacokinetics in different populations. This study aimed to investigate the influence of SLCO1B1 gene polymorphism on simvastatin treatment efficacy in a Brazilian population of European ancestry. METHODS: Two hundred and sixteen hypercholesterolemic patients were treated with 20 mg/day simvastatin for 6 months. Plasma lipid...

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Identifiers

PMID: 22505549
DOI: 10.1515/cclm.2011.804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SLCO1B1 gene variability influences lipid-lowering efficacy on simvastatin therapy in Southern Brazilians.PMID 22505549Read ↗

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