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Article

An update on efflux and uptake transporters as determinants of statin response.

Expert opinion on drug metabolism & toxicology - 1 Jun 2018

Rocha Karina Cunha E, Pereira Beatriz Maria Veloso, Rodrigues Alice Cristina

Abstract excerpt

INTRODUCTION: Statins are used in the treatment of dyslipidemia promoting primary and secondary prevention against detrimental cardiovascular events. ATP-binding cassette (ABC) and solute carrier (SLC) membrane transporters transport statins across the cell membrane. Differences in drug transporter tissue expression and activity contribute to variability in statin pharmacokinetics (PK) and response. Areas...

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Source

Identifiers

PMID: 29842801
DOI: 10.1080/17425255.2018.1482276

Genes

ABCG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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