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Article

Impact of OATP transporters on pharmacokinetics.

British journal of pharmacology - 1 Oct 2009

Kalliokoski A, Niemi M

Abstract excerpt

Membrane transporters are now recognized as important determinants of the transmembrane passage of drugs. Organic anion transporting polypeptides (OATP) form a family of influx transporters expressed in various tissues important for pharmacokinetics. Of the 11 human OATP transporters, OATP1B1, OATP1B3 and OATP2B1 are expressed on the sinusoidal membrane of hepatocytes and can facilitate the liver uptake of their...

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Blood-Brain Barrier
Intestinal Absorption
Liver-Specific Organic Anion Transporter 1
Organic Anion Transporters
Organic Anion Transporters, Sodium-Independent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pharmaceutical Preparations

Pharmacokinetics

Solute Carrier Organic Anion Transporter Family Member 1B3

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Identifiers

PMID: 19785645
DOI: 10.1111/j.1476-5381.2009.00430.x
PMCID: PMC2765590

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