Article
Impact of SLCO1B1 and ABCB1 variants on statin efficacy and toxicity in a Tunisian population.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jun 2026
Abbes Houwaida, Yassine Khalij, Meksi Maha, Meddeb Ayoub, Ajmi Marwa, Ammar Mariem, Moussa Amira, Abderahmene Amani, Gannouni Mohamed Rayen, Slim Mahdi, Amor Dorra, Boujaafer Sana, Ben Abdelaziz Asma, Hassine Refka, Abad-Santos Francisco, Zubiaur Pablo, Naffeti Ilyes, Bouslama Ali, Omezzine Asma
Abstract excerpt
Statins are the cornerstone treatment for coronary artery disease treatment. However, they exhibit considerable interindividual variability in both pharmacokinetics and pharmacodynamics. This variability was assessed by investigating 9 genetic variants impact across 5 pharmacogenes (ABCB1, CYP3A4, CETP, APOC1, and SLCO1B1) in 279 Tunisian coronary patients newly started on statins. Regarding myopathy, carrying...
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